Amicus

Multiple cell separation and photopheresis procedures

The Amicus® device offers the next step in therapeutic apheresis and photopheresis treatment.

The device offers a variety of procedures within an online, closed loop device. Amicus® is designed to tailor a range of procedures for individual patient needs. The various therapeutic and collection protocol options include:

  • Mononuclear Cell Collection (MNC)
  • Therapeutic Plasma Exchange (TPE)
  • Red Blood Cell Exchange (RBCx)
  • Extracorporeal Photopheresis (ECP)
  • Platelet Collections


One Solution for Complete Care
The Amicus® Separator and the Phelix® Photoactivation Device work in tandem to perform photopheresis procedures. Bi-directional communication between the Amicus and Phelix allows for easy control of the system from the Amicus device.

Photoactivation progress and results can be monitored and viewed from the Amicus touchscreen user interface. Amicus reinfuses the photoactivated cells back to the patient.

Scroll down for more information on these procedures.

Details

Multiprocedural application
  • MNC - High MNC collection efficiency with low platelet loss, flexible controls allow MNC settings to be adjusted quickly. Automated custom prime option for patients with lower total blood volume or lower hematocrit.
  • TPE – High efficiency in plasma removal, meaning less anticoagulant (AC) to the patient. Accurate control of liquid balance with real-time volume measurement and automatic bag change for the replacement liquid. Supports patient comfort with low extracorporeal volume.
  • RBCx – Three different procedural options including RBC exchange, RBC depletion and RBC depletion/exchange.
  • Platelets - Focused on donor comfort and safety. Highly efficient platelet collection function with simultaneous plasma and erythrocyte collection options and automatic PAS (Platelet Additive Solution) function.
  • ECP - The Extracorporeal Photopheresis protocol is an advanced procedure for the Amicus Separator that combines the Amicus MNC collection technology and the Phelix photoactivation device. After photoactivation, Amicus reinfuses the photoactivated cells into the patient.*
* The Amicus ECP system has obtained CE mark approval for the indication of CTCL in the palliative treatment of the skin manifestations of cutaenous T-cell lymphoma (CTCL) that is unresponsive to other forms of treatment.

Focused on Patient safety and comfort
  • One kit for single needle or double needle access
  • Low extracorporeal kit volume (163 ml)
  • Low minimum patient hematocrit (15%)
  • Process up to 8 litres of whole blood in 2 equal volume cycles
  • Qualified for use with ACD-A
  • Automated Custom Prime for patients having a lower total blood volume and/or lower hematocrit
  • The needle-free 8-MOP1 injection site contains a 0.2-micron antimicrobial filter combined with a one-way valve, creating a functionally closed pathway in the disposable kit
  • Patient saline option administers saline to keep access lines open
  • Real-time fluid balance tracking
  • Disposable kit irradiation sterilised to prevent the risk of patient reactions when compared with ethylene oxide sterilisation.

Seamlessly connected – DXT©
  • Amicus runs our proprietary software application designed to receive, store and transmit procedure information between Fresenius Kabi apheresis devices and external computer systems (ECS).
  • Allows for bi-directional transmission of electronic procedure record
  • Dashboard and Reporting data
  • Automatic printing of stored procedure records

Radwanski K, Burgstaler E, Weitgenant J, Dale H, Heber C, Winters J. Pilot study of a new online extracorporeal photopheresis system in patients with steroid refractory or dependent chronic graft vs host disease. J Clin Apher. 2020;35:342–350. https://doi.org/10.1002/jca.21804
 

ProductOrder UnitItem Code
Amicus® Blood Cell Separator16R4590
Amicus® Blood Cell Separator MNC16R4590TH-M
Amicus® Blood Cell Separator TPE16R4590TRH-T
Phelix Photoactivation Device16R4582
Amicus® MNC Apheresis Kit with Correct Connect6R7R2326C
Amicus® Exchange Kit TPE/ RBCx with Correct Connect6R6R2339C
Amicus® Set ECP One-/Two-Needle with Correct Connect & Sampling6X7R2346C

Blood components are collected using sterile, single-use apheresis kits. The cells are centrifugally separated within the kits by density differences.

The Amicus Blue system for Extracorporeal Photopheresis consists of:
  • Amicus Separator – A continuous-flow, centrifugal device that separates whole blood into its components.
  • Phelix Photoactivation device - Continuously monitors the intensity of UVA light, temperature of the collected MNCs and agitation to ensure delivery of the target UVA light dose.
  • Single-use disposable kits – This kit is designed for use with the Amicus Separator and the Phelix Photoactivation device for the administration of Extracorporeal Photopheresis (ECP).

Amicus Separator:
Seperation methodCentrifugation
Procedure typesSingle and double needle
Product quality≈90% MNCs; ≈2% Hct
AnticoagulantACD-A
Whole Blood processDefault: 2000 mL, Range: 500 - 8000 mL
Extracorporeal volume163 mL
Min. patient hematocrit15 mL

Phelix Photoactivation device:
UVA light producedApproximately 1.5 J/cm2
UVA bulb wavelength315 - 400 nm
Surface UVA intensity15 mW/cm2

Amicus Separator:
Transportation heightApproximately 132.1 cm (52 in) or lower
Power cord length2.5 m (8 ft) Europe
TemperatureThe separator and apheresis kit are designed to work properly when temperatures are between 15.5° C (60° F) and 32.2° C (90° F).

The AMICUS separator can be stored for up to six months at a temperature between 0° C (32° F) and 50° C (122° F) with a relative humidity less than 85% at 40° C (104° F).
Weight6R4590 282 lbs (128 kg)
6R4590TH-M, 6R4590TH-T 317 lbs (144 kg)
Operating noise55dbA. (approx.)

Phelix:
Height x Width x Depth28.0 cm x 34.3 cm x 72.4 cm
TemperatureOperating: 15.5 to 28° C (60 to 82° F)
Storage: 0 to 50° C (32 to 122° F)
WeightApproximately 24kg
UVA bulbsLife: 500
Operating noise50 dbA

 

Please note: For Healthcare Professional Use Only

Platelets and MNC are a collective procedure and not a therapeutic application.

 

Job code August 2025

1 (psoralen, 20 μg/mL)- Not supplied by Fresenius Kabi​

Always refer to the instructions for use (IFU) and operator's manual for a complete list of warnings and precautions associated with the use of this product and associated products.