PreparePlus® PN is a reliable software program for assessing the compatibility and stability of parenteral nutrition admixtures prescribed for individual patients.
The extensive database compiled over many years supports you in evaluating new compositions. Rather than extrapolations from the literature or stability equations, all stable results given by PreparePlus® PN are based on actual laboratory stability tests using the well established Fresenius Kabi range concept, which tests the stability of components of mixtures within a wide range of volumes, rather than just fixed volumes. This approach gives maximum flexibility for the addition of all admixture components. In addition, the compounding process is facilitated by the generation of worksheets and labels. Documentation of patients data and PN treatment can easily be tracked and recalled.
If you have any questions, please do not hesitate to contact us.

The signs/names marked with ® are registered trademarks of the Fresenius Group in selected countries.

Admixtures for parenteral nutrition (PN) are very complex in terms of physical and chemical compatibility as they contain a broad range of components in various amounts and numerous combinations. It is not necessarily safe to simply mix all components as prescribed for a nutritionally appropriate prescription. The admixture must also be assessed for compatibility and stability. Therefore the recommendation is to “mix all components (…) only within limits based on reliable information from the manufacturers, specific analytical test and/or the peer-reviewed literature” and further more “to prepare AIO [All-in-one] admixtures under pharmaceutical supervision, following validated guidelines for types and amounts of macro- and micronutrients, under rigorously controlled order and conditions of mixing (standard operation procedures, GMP).” 1). PreparePlus® PN allows you to access data from the results of specific analytical tests carried out by Fresenius Kabi and is a reliable software program for assessing the compatibility and stability of PN admixtures prescribed for individual patients.

1) Mühlebach S, DF Driscoll. Stability and compatibility of parenteral nutrition (PN) admixtures. In: Sobotka L et al., eds. ESPEN: Basics in clinical nutrition. 4th ed. Prague: Publishing House Galen, 2011: 384-392.

The signs/names marked with ® are registered trademarks of the Fresenius Group in selected countries.

Link to E-learning course​​

1. What is PreparePlus® PN about?

Admixtures for parenteral nutrition (PN) are very complex in terms of physical and chemical compatibility as they contain a broad range of components in various amounts and numerous combinations. Assessing this is complex and requires time, knowledge and experience. Fresenius Kabi takes your request for reliable and extensive compatibility data seriously and continuously investigates new compositions. To make this data available to you, PreparePlus® PN has been developed. At your finger tips, you will have a new, high performance, ready to use, intelligent software, setting new standards for PN compounding.

2. What are the key features of PreparePlus® PN?

• PreparePlus® PN makes admixing easier by:
• Consistently checking for compatible and stable admixtures
• Offering specific advice to amend unstable admixtures to make them stable
• Providing stability statements, work sheets, and even labels
• Enabling you to file and follow each patient’s nutritional programme

3. Why choose PreparePlus® PN?

• Available whenever you need it
• Immediate access to updates
• Easy to use with an intuitive user-friendly interface
• Supports both adult and paediatric PN regimens

4. What makes PreparePlus® PN so exceptional?

• GMP-validated and certified software
• Extensive database compiled over many years
• All results are based on actual laboratory stability tests
• Intelligent guidance based on a unique search algorithm

5. How will PreparePlus® PN help you to save time?

• Immediate access to reliable compatibility data 
• Clear advice on the process of mixing 
• Automatic production of stability statements, work sheets and labels 
• Support tools for concentration calculations or conversion of units

6. Where did the data in PreparePlus® PN come from?

Rather than extrapolations or stability equations, all stable results given by PreparePlus® PN are based on actual laboratory stability tests using the well-established Fresenius Kabi range concept, which tests the stability of components of mixtures within a wide range of volumes, rather than just fixed volumes. This approach gives maximum flexibility for the addition of all admixture components.

7. How does PreparePlus® PN work?

Just enter the nutritional needs of the patient in terms of either the products or the components. Then click “check stability” and PreparePlus® PN will indicate if your PN regimen is compatible and for how long.

Should your regimen be unstable, PreparePlus® PN will help you to customise your formulation to obtain stability. PreparePlus®PN offers suitable advice and furthermore has an intuitive interface with a red-green scale indicating your current position within the tested range to simply edit the admixture!

Now you can rest assured - you can rely on admixtures found to be compatible and stable by PreparePlus® PN!

8. Is the software Web-based?

PreparePlus® PN is to be used offline. This is because it is more than just compatibility check software. It is designed to support the pharmacists in the compounding process, which means preparing compounded bags for named patients. Patient productions are recorded in the system according to GMP requirements. Thus, for reasons of data protection, PreparePlus®PN will be used locally offline. However, you are encouraged to go on-line at regular intervals to see if any updates are available to be downloaded.

9. Is PreparePlus® PN validated?

PreparePlus® PN is classified as GAMP® 5 Category 5 (Custom Application) software and has been validated accordingly. A validation team was established, who carried out and documented a stringent validation process. A signed certificate with approval date of 5th May 2011 is available to reassure you of the validated status of PreparePlus® PN.

10. How can I get PreparePlus® PN?

PreparePlus® PN will be given to you on a CD ROM and installed by your local Fresenius Kabi representative. They will also provide you with an extensive User Manual and a step-by-step Getting Started Guide.

11. What do I need to be prepared for PreparePlus® PN?

You just need a computer running with Windows 2000 SP4 or higher, an internet connection/CD-ROM drive for updates, which will be available free of charge, and a printer. The program includes a help functionality to guide you along the way.

The signs/names marked with ® are registered trademarks of the Fresenius Group in selected countries.​