Aminosteril N-Hepa 8%

Complete and balanced amino acid profile for effective hepatic encephalopathy treatment
High concentration of branched chain AA and reduced concentration of aromatic AA
Low methionine concentration
High arginine concentration
Effective in maintaining a nitrogen balance
Normalization of pathological plasma amino acid levels
Reduced likelihood of metabolically produced toxic amines

Holm E., Striebel JP., Möller P., Hartmann M. Amino aid solution for parenteral nutrition ad for adjunct treatment of encephalopathy in liver cirrhosis. Studies concerning 120 patients. In Metabolism and clinical implications of branched chain amino and ketoacids (Eds Walser M and Williamson JR, Elsevier North Holland, NY, Amsterdam 1981, pp510-518.
Holm E, Striebel JP, Meisinger E, Haux P, Langhans W, Becker HD. Aminosäurengemiche zur parenteralen Ernährung bei Leber-insuffzienz. Infusionstherapie 1978; 5:274-292.
Kato M., Miwa Y., Tajika M., Hiraoka T., Muto Y., Moriwaki H. Preferential use of branch-chain amino acids as an energy substrate in patients with cirrhosis. Intern Med 1998; 37:429-434.
Naylor CD., O’Rourke K., Detsy AS, et al. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. A meta-analysis. Gastroenterology. 1989;97:1033-1042.
Fiene R., Holm E., Dietl H., Mezitis N., Schuler A. Parenteral nutrition with amino acids in hepatic insufficiency. Dt Ges Inn Med 1977; 83:533-537.
Freund H., Fischer J. Our experience with F080 in the treatment of hepatic coma in 63 patients. In Amino acid and ammonia metabolism in hepatic failure. (Ed Holm E). Witzstrock, Baden-Baden-Köln NY, 1982, pp172-183.
Rakette S., Reimann H-J., Fischer M., Bottermann P. Therapeutic influence on hepatic encephalopathy in patients with cirrhosis of the liver using a special amino acid solution: Biochemical and clinical findings. In Hrsg. Aminosären-und Ammoniakstoff-wechsel bei Leberinsuffizienz. (Ed Holm E). Witzstrock, Baden- Baden-Köln NY, 1982, pp203-210.
Cerra FB., Cheung NK, Fischer JE., et al. A multicenter trial of branched chain enriched amino acid infusion (F080) in hepatic encephalopathy . Hetatology 1982;2:699.
Fischer JE. Branched-chain-enriched amino acid solutions in patients with liver failure: an early example of nutritional pharmacology. JPEN 1990; 14(5):249S-256S.
Holm E, Leweling H, Striebel JP, Specker M, Weber T. Parenteralen Ernährung bei Leberinsuffzienz. In Parenteralen Ernährung. Eigler FW (ed) Zuckschwerdt Verlag, Munchen, Bern, Wien 1983;184-223.
Lochs H, Plauth M. Liver cirrhosis: rationale and modalities for nutritional support – the European Society of Parenteral and Enteral Nutrition consensus and beyond. Curr Opin Clin Nutr Metab Care 1999;2:345-349.
Fiaccadori F., Chinelli F., Pedretti G, Sacchini D. Different nutritional approaches in liver cirrhosis: Effects of nitrogen balance: preliminary report. Front. Gastrointest Res. 1984;8:254-265.
Marchesini G., Bianchi G., Rossi B., Brizi M., Melchionda N. Nutritional treatment with branched-chain amino acids in advanced liver cirrhosis. J Gastroenterol 2000;35 Suppl 12:7-12.
Wahren J., Denis J., Desurmont P., et al. Is intravenous administration of branched chain amino acids effective in the treatment of hepatic encephalopathy? A multicenter study. Hepatology 1983;3(4):475-480.
Cerra FB., Cheung NK., Fischer JE., Kaplowitth N., Schiff ER., Dienstag JL., Bower RH., Mabry CD., Leevy CM., Kiernan T. Disease-specific amino acid infusion (F080) in hepatic encephalopathy : a prospective , randomised, double-blind, controlled trial. JPEN 1985;9:288-295.
Rakette S., Fischer M., Reimann HJ., and von Sommoggy S. Effects of special amino acid solutions in patients with liver cirrhosis and hepatic encephalopathy. In Metabolism and clinical implications of branched-chained and amino-and ketoacids. Walser M., Williamson JR (eds). ElsevierlNorth Holland, New York, Amsterdam 1981;419-425.
Michel H., Pomier-Layrargues G., Aubin JP., et al. Treatment of hepatic encephalopathy by infusion of a modified amino acids solution: Results of a controlled study in 47 cirrhotic patients. In Hepatic encephalopathy ii chronic liver disease (Eds Capacaccia L, Fischer JE., Rossi-Fanelli F). Plenum Press 1984, pp301-310.
Fischer JE., Harvey MR., Ebed AM., et al. The effect of normalisation of plasma amino acids on hepatic encephalopathy in man. Surgery 1976;80:77-91.
Gerok W. Aminosaurenstoffwechsei bei Leberinsuffizienz.Verh Dtsch Ges f Inn Med 1969;75:33.
Carolyn RJ., Grifffith DP., Bergman GF., Leader LM., and Ziegler TR. Nutrient Pharmacotherapy. In clinical Nutrition. Parenteral Nutrition 3rd edition. Rombeau JL., and Rolandelli RH. WB Saunders. New York, London 2001;562-587.
Reiter HJ., Bode JC. Parenteral application of a special amino acid solution in the treatment of severe hepatic encephalopathy. Zeitschrift für Gastroenterology. 1978;7:457-464.
Saurezl., Bodega G., and Fernandez B. Glutamine synthetase in the brain: effect of ammonia. Neurochem Int 2002;41:123-142.
Blei AT, Olafsson S, Therrien G, Butterworth FR. Ammonia-induced brain edema and intracranial hypertension in rats after portocaval anastomosis. Hepatology 1994;19:1337-1444.
Fan P, Lavoie J, Le O, Szerb JC, Butterworth RF. Neurochemical and electrophysical studies on the inhibitory affect of ammonium ionns on synaptic transmission in slices of rat hippocampus: Evidence for a postsynaptic action. Neuroscience 1990;37:328-334.
Raabe WA, Neurophusiology of ammonia intoxication. In Butterworth RF, Layrargues P (eds) Hepatic encephalopathy: Pathophysiology and treatment. Humana Press, Clifton 1989; 49-77.
Butterworth FR. Portal-systemic encephalopathy: a disorder of neuron-astrocytic metabolic trafficking. Dev Neurosci 1993;15:313-319.
Hazell AS., Buterworth RF. Hepatic encephalopathy: An update of pathophysiologic mechanisms. Proc Soc Exp Biol Med 1999;222:99-112.
James JH., Ziparo V., Jeppson B., Fisher JE. Hyperammonaemia, plasma amino acid imbalance, and blood brain amino acid transport: a unified theory of portal systemic encephalopathy . Lancet 1979;2:772-775.
Plauth M, Merli M, Kondrup J, Weiman A, Ferenci P, Muller MJ. ESPEN guidelines for nutrition in liver disease and transplantation. Clin Nutr 1997; 16:43-55.
Mizock BA. Nutritional Support in hepatic encephalopathy . Nutrition 1999;15:220-228.

Characteristics	Aminsterile N Hepa
AA gms	40 gm
BCAA	42 %
AAA	2 %
Arginine	13.4 %
Total Nitrogen (g/l/pack)	12.9
Total Kcals/l	320
Osmolarity (mosmol/L)	770
Infusion Rate	1.25 ml/kg body wt/hr
Max.Dosage (ml/kg bw/day)	18.75
Shelf life (months)	36
Route of Adm	Peripheral

Aminosteril N-Hepa 8%

Features

Indication

Dosage

Benefits

References

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