Dipeptiven je infúzny koncentrát dipeptidu alanyl-glutaminu. Dipeptid alanylglutamín sa endogénne štiepi na aminokyseliny alanín a glutamín, čím je umožnený prísun glutamínu v infúznom roztoku pre parenterálnu výživu1.
Glutamín hrá v tele kľúčovú úlohu v dusíkovej bilancii2.
Pozitívne účinky suplementácie glutamínom v stresových podmienkach:
1. SPC Dipeptiven, www.sukl.sk
2.Buter H, Bakker AJ, Kingma WP et al. Plasma glutamine levels in patients after nonelective or elective ICU admission: An observational study. BMC Anesthesiol 2016; 16:15
3. Déchelotte P, Hasselmann M, Cynober L et al. L-alanyl-Lglutamine dipeptide supplemented total parenteral nutrition
reduces infectious complications and glucose intolerance
in critically ill patients: the French controlled, randomized,
double-blind, multicenter study. Crit Care Med 2006;
34(3):598–604.
4. Bollhalder L, Pfeil AM, Tomonaga Y et al. A systematic
literature review and metaanalysis of randomized clinical
trials of parenteral glutamine supplementation. Clin Nutr
2013; 32(2):213–23.
5. Wischmeyer PE, Dhaliwal R, McCall M et al. Parenteral
glutamine supplementation in critical illness: a systematic
review. Critical care. 2014;18(2):R76.
6. Tao K-M, Li X-Q, Yang L-Q et al. Glutamine supplementation for critically ill adults. Cochrane Database Syst Rev 2014; (9):CD010050.
7. Pradelli L, Povero M, Muscaritoli M et al. Updated costeffectiveness analysis of supplemental glutamine for
parenteral nutrition of intensive-care patients. Eur J Clin
Nutr 2015; 69(5):546–51.
Glutamín hrá v tele kľúčovú úlohu v dusíkovej bilancii2.
Pozitívne účinky suplementácie glutamínom v stresových podmienkach:
- Nižšie riziko infekčných komplikácií3,4
- Skrátenie dĺžky hospitalizácie4,5
- Kratšia dĺžka mechanickej ventilácie6
- Preukázaná nákladová efektívnosť7
1. SPC Dipeptiven, www.sukl.sk
2.Buter H, Bakker AJ, Kingma WP et al. Plasma glutamine levels in patients after nonelective or elective ICU admission: An observational study. BMC Anesthesiol 2016; 16:15
3. Déchelotte P, Hasselmann M, Cynober L et al. L-alanyl-Lglutamine dipeptide supplemented total parenteral nutrition
reduces infectious complications and glucose intolerance
in critically ill patients: the French controlled, randomized,
double-blind, multicenter study. Crit Care Med 2006;
34(3):598–604.
4. Bollhalder L, Pfeil AM, Tomonaga Y et al. A systematic
literature review and metaanalysis of randomized clinical
trials of parenteral glutamine supplementation. Clin Nutr
2013; 32(2):213–23.
5. Wischmeyer PE, Dhaliwal R, McCall M et al. Parenteral
glutamine supplementation in critical illness: a systematic
review. Critical care. 2014;18(2):R76.
6. Tao K-M, Li X-Q, Yang L-Q et al. Glutamine supplementation for critically ill adults. Cochrane Database Syst Rev 2014; (9):CD010050.
7. Pradelli L, Povero M, Muscaritoli M et al. Updated costeffectiveness analysis of supplemental glutamine for
parenteral nutrition of intensive-care patients. Eur J Clin
Nutr 2015; 69(5):546–51.