Intralipid®

Intralipid

Features

Intravenous nutrition to supply energy and essential fatty acids

Patients with essential fatty acid deficiency (EFAD) who cannot maintain or restore a normal essential fatty acid pattern by oral intake

Benefits

  • Minimizes hyperglycemia
  • Reduces metabolic stress
  • Improves protein utilisation
  • Prevents fatty infiltration of the liver
  • Preserves hepatic function
  • Reduces respiratory stress

Indications

  • Indicated in patients needing intravenous nutrition to supply energy and essential fatty acids. Intralipid is also indicated in patients with essential fatty acid deficiency (EFAD) who cannot maintain or restore a normal essential fatty acid pattern by oral intake.
  • Paediatric indication for Intralipid 10% and 20%.

 

Packaging / Dosage

10%,20%,30% Intralipid, (100ml, 250ml and 500ml) glass bottles

Prematures and low birthweight neonates:  0.5-1 g/kg body wt/day followed by a successive  increase by 0.5-1 g/kg body wt/day up to 2g/kg bw/day.

Neonates and infants: 0.5-4 g TG/kg body wt/day.

Adults : up to 3 g TG/kg body wt/day

Product Information

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Characteristics

Intralipid 10%

Intralipid 20%

Intralipid 30%

Soybean oil (g/l)

100

200

300

Egg phospholipids (g/l)

12

12

12

Glycerol (g/l)

22

22

16.7

pH

8

8

8

Osmolality (mosm/kg water)

300

350

310

Osmolarity (mosm/l)

260

260

200

Energy (kcal/l)

1100

2000

3000

Phosphate (mmol/l)

15

15

15

Phospholipid/TG ratio

0.12

0.06

0.04

Shelf life (months)

24

24

24

Route of Adm

peripheral

peripheral

peripheral

Reference

  1. Singer P et al. Clin Nutr 2009, 28:387-400.
  2. Nordenström J et al. Clin Physiol 1981, 1:525-534.
  3. Garcia-de-Lorenzo A et al. JPEN 2003, 27:208-215.
  4. Demling RH et al. J Burn CareRehabil. 1985, 6:222-225.
  5. Enzi G et al. Crit Care Med 1990, 18:719-721.
  6. Roulet M et al. Clin Nutr 1983, 2:97-105.
  7. Nanni G et al. J Trauma 1984, 24:14-30.
  8. Caresta E et al. Pediatr Res 2007, 61:228-232.
  9. Kalfarentzos F et al. Clin Nutr 1998, 17:31-34.
  10. Puiggros C et al. Enteral Nutr 2009, 33:501-512.
  11. Dionigi P et al. Clin Nutr 1985, 4:229-234.
  12. Shaw JH et al. Enteral Nutr 1988, 12:433-440.
  13. Nagayama M et al. Nutrition 1991, 7:267-270.
  14. Socha P et al. Nutrition 2007, 23:121-126.
  15. Korzets A et al. J Ren Nutr 1999, 9:206-213.
  16. Lee HA et al. Postgrad Med J 1967, 43:81-91.
  17. Szczygiel B et al. J Clin Nutr Gastroenterol 1991, 6:203-213.
  18. Silberman H et al. Am J Gastroenterol 1982, 77:494-497.
  19. Wu H et al. Zhonghua Wai Ke Za Zhi 1995, 33:261-264.
  20. Goulet O et al. Am J Clin Nutr 1999, 70:338-345.
  21. Webb AN et al. Nutrition 2008, 24:1057-1064.
  22. Deshpande GC et al. J Pediatr Gastroenterol Nutr 2009, 49:619-625.
  23. Göbel Y et al. J Pediatr.Gastroenterol Nutr 2003, 37:161-167.
  24. Bouletreau P et al. Nutr Clin Metabol 1996, 10:33-36.
  25. Garnacho-Montero J et al. Nutrition 2002, 18:134-138.
  26. Chen FM et al. Kaohsiung J Med Sci 2005, 21:487-494.
  27. Mateu-de Antonio J et al. Br J Nutr 2008, 99:846-854.
  28. Goulet O et al. Nutrition 1992, 8:333-337.
  29. Wirtitsch M et al. Clin Nutr 2007, 26:302-313.
  30. Reimund JM et al. Aliment Pharmacol Ther 2005, 21:445-454.
  31. Roggero P et al. Nutrition 2009 online.
  32. Cipierre C et al. Acta Pediatrica 2009, 98:44-45.
  33. Tulikoura I et al. Scand J Gastroenterol 1982, 17:177-185.
  34. Buchmiller CE et al. JPEN 1993, 17:301-306.
  35. Askanazi J et al. Anesthesiology 1981, 54:373-377.
  36. Braga M et al. Clin Nutr 2009, 28:378-386.
  37. Ziegler TR. N Engl J Med 2009, 361:1088-1097.