SMOFlipid®

SMOFlipid

​Lipid emulsion for parenteral nutrition containing four different types of oils.

Features

  1. The unique, well-balanced lipid emulsion with purified natural fish oil
  2. 30% soybean oil as reliable source of essential fatty acids
  3. 30% medium-chain triglycerides (MCT) as source of rapidly available energy
  4. 25% olive oil for supply of monounsaturated fatty acids, especially oleic acid
  5. 15% fish oil provides ω-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)
  6. Additionally vitamin E (approximately 200 mg a-tocopherol/L)
  7. Fatty acid pattern with respect to saturated fatty acids, monounsaturated fatty acids, and essential fatty acids is similar to human milk
  8. Extensive compatibility and stability data are available with a wide range of admixtures

Benefits

Positive impact on liver cell function and integrity

Favourable immune and inflammatory response

For adequate antioxidative protection

To prevent antioxidant depletion

Reduced length of hospital stay

Indications

SMOFlipid is indicated in patients who needs intravenous nutrition to supply energy, essential fatty acids and omega-3 fatty acids

Packaging / Dosage

20% SMOF, (100ml, 250ml, 500ml) glass bottle,

Adult: Standard dose: 1.0 – 2.0 g fat/kg body wt

Neonates & infants: 0.5 – 1.0g fat/kg body wt/day, Followed by: 0.5 -1.0 g fat/kg body wt/day up to 3.0 g fat/kg body wt/day

Children: It is recommended not to exceed a daily dose of 3 g fat/kg body wt/day.  Daily dose gradually increased during first week

Product Information

Characteristics:

SMOFlipid 20%

Soybean oil, refined:     

60g

Triglycerides, medium-chain:     

60g

Olive oil, refinded:          

50g

Fish oil, rich in omega-3-acids:   

30g

Esential fatty acids

21%

Total Energy (kcal/l)

2000

pH-Value

approx. 8

Osmolality

approx. 387 mosm/kg

Osmolarity

290mosm/l

w-6/w-3 fatty acid ratio

2.5:1

Shelf life (months)

24

Route of Adm

peripheral/central

 
   

Reference

  1. Piper SN et al. EJA 2009; 26: 1076-1082
  2. Antebi H et al. JPEN 2004; 28:142 – 148
  3. Schade I et al. Crit Care 2008; 12 (Suppl 2) S56–S57
  4. Grimm H et al. EJN 2006; 45:55–60
  5. Mertes N et al Ann. Nutr. Metab. 2006; 50:253-259
  6. Tomsits E et al. Journal of Pediatric Gastroenterology & Nutrition 2010; 51:514-52
  7. Klek S et al. Clin Nutr. 2012; epub ahead of print (http://dx.doi.org/10.1016/j.clnu.2012.06.011