The recommended premedication dose of Midazolam for adult patients below the age of 60 years is 0.07 to 0.08 mg/kg administered about 1 hour before surgery. When used for conscious sedation, dosage must be individualized and titrated. Induction of Anaesthesia: Unpremedicated Patients: In the absence of premedication, an average adult under the age of 55 years will require an initial dose of 0.3 to 0.35 mg/kg for induction, administered over 20 to 30 seconds and allowing 2 minutes for effect. If needed increments of approximately 25% of the patient's initial dose may be used to complete induction. In resistant cases, up to 0.6 mg/kg may be used for induction, but such large doses may prolong recovery. Unpremedicated patients over the age of 55 years usually require less Midazolam for induction; an initial dose of 0.3 mg/kg is recommended. Unpremedicated patients with severe systemic disease or other debilitation usually require less Midazolam for induction. An initial dose of 0.2 to 0.25 mg/kg will usually suffice; in some cases, as little as 0.15 mg/kg may suffice.
For preoperative sedation
For conscious sedation prior to short diagnostic or endoscopic procedures.
For induction of general anaesthesia prior to administration of other anaesthetic agents