Kabiceftam

The antibacterial component of sulbactam/cefoperazone is cefoperazone, a third- generation cephalosporin, which acts against sensitive organisms during the stage of active multiplication by inhibiting the biosynthesis of cell wall mucopeptide. Sulbactam does not possess any useful antibacterial activity, except against Neisseriaceae and Acinetobacter.  As sulbactam also binds with some penicillin-binding proteins, sensitive strains are also often rendered more susceptible to sulbactam/cefoperazone than to cefoperazone alone.

Packaging:
Kabiceftam 1.5 g: Supplied as clear 20 ml USP type-III moulded glass vial with 10 ml SWFI.
Kabiceftam 3 g: Supplied as clear 20 ml USP type-III moulded glass vial with 10 ml SWFI.

Dosage: 
The usual adult dose of combination is 2 to 4 g/day (i.e. 1-2 g/day each of Cefoperazone and Sulbactam) given IV or IM in equally divided doses every 12 hours. In severe or refractory infections the daily dosage may be increased to 8 g (i.e. 4 g/day each of Cefoperazone and Sulbactam) given IV in equally divided doses every 12 hours. The recommended maximum dosage of Sulbactam is 4 g (8 g of the combination). 
 

It is indicated for the treatment of following infections when caused by susceptible organisms:
•    Respiratory tract infections (upper and lower)
•    Urinary tract infections (upper and lower)
•    Peritonitis, cholecystitis, cholangitis, and other intra-abdominal infections
•    Septicaemia
•    Meningitis
•    Skin and soft tissue infections
•    Bone and joint infections
•    Pelvic inflammatory disease, endometritis, gonorrhoea, and other infections of the genital tract
 

Each combipack contains:
(a)    1 vial of Cefoperazone & Sulbactam for Injection
        Each vial contains:
Cefoperazone Sodium IP (Sterile) - 1 gm/2 gm
Sulbactam Sodium USP (Sterile) – 0.5 gm/1 gm
(b)    1 Ampoule of Sterile Water for Injections IP
        Each ampoule contains:
Sterile Water for Injections IP – 10 ml