​Amino acid solution for parenteral nutrition containing dipeptide alanyl-glutamine


  1. Available as L-alanyl-L-glutamine dipeptide in 20% 50ml and 100 ml solution
  2. Glutamine is conditionally essential amino acid for use in highly catabolic patients
  3. Glutamine forms 60% of free amino acid pool in the muscles and should be administered as part of amino acid supplementation in parental nutrition
  4. Dipeptide technology ensures stability on heat sterilization
  5. Systemic role of glutamine:
  • Supports glutathione synthesis
  • Increases cellular defence mechanism
  • Fuel for Entrocytes and immune cells
  • Is a nitrogen donor
  • Reduces insulin resistance


  • May improve survival rate and reduce 6-month mortality rate
  • Reduced length of hospital stay
  • Reduced infectious complications
  • Reduced rates of hyperglycemia
  • Gut integrity maintained
  • Improved nitrogen balance
  • Strengthened immune defense


  •  Dipeptiven is indicated as part of an intravenous parenteral nutrition regimen as a supplement to amino acid solutions or an amino acid containing infusion regimen, e.g. in patients in hypercatabolic and/or hypermetabolic states

Packaging / Dosage

20%, 50ml and 100ml glass bottles

  • Depends on severity of the catabolic state & on amino acid requirement
  • 1.5 -2.5 ml/kg body wt. (=100 to 175 ml Dipeptiven for a patient of 70 kg body weight)
  • Rate of infusion should not exceed 0.1g amino acids/kg body wt./hr
  • Duration of use should not exceed 3 weeks
  • Not designed for direct administration
  • Should be mixed with a compatible amino acid carrier solution or an amino acid containing infusion regimen
  • 2g amio acids/kg body wt. should not be exceeded in PN
  • Proportion of amino acid supplied through Dipeptiven should not exceed ~30% of total amino acid
  • 2.5ml or 0.5g N(2)-L-alanyl-L-glutamine of Dipeptiven per kg body weight.

Product Information



AA gms


Total Nitrogen (g/l/pack)


Total Kcals/100ml


Osmolarity (mosmol/L)


Infusion Rate

8 drops/min, should not exceed 0.1g AA/kg/hr

Max.Dosage (ml/kg/day)


Shelf life (months)


Route of Adm





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31.Glutamine product information binder. Dipeptiven®, Glamin®: parenteral nutrition.

Version 2, January 2006. Fresenius Kabi, data on file.

32.Dipeptiven (L-alanyl-L-glutamine). Summary of product characteristics