OXITAN (Oxaliplatin) is a platinum-based drug, usually classified as alkylating group.
Mechanism of action:
OXITAN (Oxaliplatin) is an antineoplastic agent, belonging to a new class of platinum compounds that contains a platinum atom complexed with oxalate and diaminocyclohexane (DACH). It exhibits a broad spectrum of cytotoxic activity in vitro and anti-tumour activity in vivo in various tumour model systems, including models of colorectal cancer in man. Studies on the mechanism of action (though this has not been fully elucidated) show that the hydrated derivatives resulting from the biotransformation of OXITAN (Oxaliplatin) interact with DNA to form intra and inter-strand bonds, causing an interruption in DNA synthesis, which is the reason for its cytotoxic and anti-tumour activities.