DAXOTEL

DAXOTEL (Docetaxel) 20mg/ml Concentrate for Solution for Infusion

Features

DAXOTEL (Docetaxel) is an antimitotic drug used for chemotherapy.

ATC-Code: L01CD02

Mechanism of action:

DAXOTEL (Docetaxel) is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions. It binds to free tubulin and promotes the assembly of tubulin into stable microtubules while simultaneously inhibiting their disassembly. This leads to the production of microtubule bundles without normal function and to the stabilization of microtubules, which results in the inhibition of mitosis in cells. DAXOTEL (Docetaxel)’s binding to microtubules does not alter the number of protofilaments in the bound microtubules, a feature which differs from most spindle poisons currently in clinical use.

Therapeutic Indications

DAXOTEL (Docetaxel) is indicated:

  • For the treatment of patients with locally advanced or metastatic breast carcinoma
  • For the treatment of patients with locally advanced or metastatic non-small cell lung cancer
  • For the treatment of patients with metastatic carcinoma of the ovary after failure of first-line or subsequent chemotherapy
     
  • In combination with prednisone or prednisolone, for the treatment of patients with hormone refractory metastatic prostate cancer
     
  • In combination with cisplatin and 5-fluorouracil, for the treatment of patients with metastatic gastric adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, who have not received prior chemotherapy for metastatic disease
     
  • In combination with cisplatin and 5-fluorouracil, for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck

Presentation

Strength is denoted by disposable cap colour. 

Strength

Packaging

Pack Size*
20 mg/1 ml 1ml clear glass vial 1
80 mg/4 ml 4ml clear glass vial 1
120 mg/6 ml 6ml clear glass vial 1
160 mg/8 ml 8ml clear glass vial 1
180 mg/9 ml 9ml clear glass vial 1

* Not all pack sizes may be marketed or available locally.
* Product images are for illustration purposes only. 

Product Information

​Please note that this product may not be available in all countries due to different registration status. Additionally, approved indications, contraindications, side effects, warnings and all other product characteristics may differ between countries.

If you require any information, please contact your local organization.