Technology

HESylation® - Technology

 

In comparison to other marketed technologies, HESylation differs significantly:

 

• Safety
  HES is a modified naturally derived polymer that is produced from waxy maize starch. It has been widely used in clinical practice for decades as a plasma volume expander. Consequently, HES has an impressive and well documented safety record.

 

• Metabolism
  HES is known to be metabolised by body enzymes and is thus able to be renally excreted from the body.

 

• Chemical properties of HES
  HES, as a substituted starch polymer, is a poly-disperse molecule by nature. It can be altered by our proprietary technology regarding size, and degree of substitution, branching, poly-dispersity etc. This enables the customizing of pharmacokinetics, onset, duration and level of activity as well as the kinetics of metabolism along with coupling chemistry strategies. Generating a drug molecule with unique properties supported by a strong patent position, is the clear objective.