HESylation® - Technology
In comparison to other marketed technologies, HESylation differs significantly:
HES is a modified naturally derived polymer that is produced from waxy maize starch. It has been widely used in clinical practice for decades as a plasma volume expander. Consequently, HES has an impressive and well documented safety record.
HES is known to be metabolised by body enzymes and is thus able to be renally excreted from the body.
- Chemical properties of HES
HES, as a substituted starch polymer, is a poly-disperse molecule by nature. It can be altered by our proprietary technology regarding size, and degree of substitution, branching, poly-dispersity etc. This enables the customizing of pharmacokinetics, onset, duration and level of activity as well as the kinetics of metabolism along with coupling chemistry strategies. Generating a drug molecule with unique properties supported by a strong patent position, is the clear objective.